Adriano Aguzzi Selected Research

Amyloid (Amyloid Fibrils)

11/2023	Whole-brain microscopy reveals distinct temporal and spatial efficacy of anti-Aβ therapies.
11/2017	Absolute Quantification of Amyloid Propagons by Digital Microfluidics.
1/2016	Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport.
1/2016	Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting.
11/2014	Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).
9/2013	A template for new drugs against Alzheimer's disease.
6/2013	BSE-associated prion-amyloid cardiomyopathy in primates.
10/2012	Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years.
12/2009	An analytical solution to the kinetics of breakable filament assembly.
11/2009	Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.

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Adriano Aguzzi Research Topics

Disease

102	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2023 - 10/2000
55	Infections 01/2023 - 01/2002
36	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 07/2004
29	Scrapie 01/2021 - 01/2002
22	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2024 - 01/2002
22	Alzheimer Disease (Alzheimer's Disease) 11/2023 - 05/2003
8	Bovine Spongiform Encephalopathy (Mad Cow Disease) 01/2021 - 07/2004
8	Sporadic Creutzfeldt-Jakob Disease 01/2015 - 11/2003
7	Parkinson Disease (Parkinson's Disease) 01/2023 - 01/2002
7	Neoplasms (Cancer) 11/2022 - 04/2004
7	Inflammation (Inflammations) 11/2017 - 02/2005
6	Amyloidosis 02/2024 - 08/2009
6	Amyloid Plaque 11/2023 - 01/2008
6	COVID-19 08/2022 - 02/2021
6	Proteostasis Deficiencies 11/2021 - 12/2008
5	Brain Diseases (Brain Disorder) 01/2024 - 06/2004
5	Disease Progression 01/2021 - 11/2010
5	Neuroinflammatory Diseases 01/2021 - 11/2017
4	Neuroblastoma 01/2019 - 07/2005
4	Gliosis 01/2019 - 04/2004
4	Chronic Wasting Disease 01/2014 - 07/2004
3	Dementia (Dementias) 01/2023 - 10/2012
3	Tauopathies 05/2021 - 01/2012
3	Communicable Diseases (Infectious Diseases) 01/2019 - 06/2004
2	Glioblastoma (Glioblastoma Multiforme) 02/2024 - 05/2002
2	Synucleinopathies 01/2023 - 01/2019
2	Multiple System Atrophy 01/2023 - 10/2022
2	Cognitive Dysfunction 01/2022 - 11/2012
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021 - 02/2005
2	Kuru 11/2018 - 01/2009
2	Polyneuropathies (Polyneuropathy) 01/2016 - 03/2010
2	Disease Susceptibility (Diathesis) 07/2012 - 01/2009
2	Seizures (Absence Seizure) 07/2010 - 09/2007
2	Hepatocellular Carcinoma (Hepatoma) 10/2009 - 01/2002
2	Astrocytoma (Pilocytic Astrocytoma) 04/2004 - 05/2002
2	Glioma (Gliomas) 04/2004 - 05/2002
1	Stroke (Strokes) 02/2024
1	Infarction (Infarctions) 02/2024
1	Transthyretin-Related Hereditary Amyloidosis 02/2024
1	TDP-43 Proteinopathies 02/2024
1	Post-Acute COVID-19 Syndrome 01/2024
1	Thromboinflammation 01/2024
1	Cerebellar Diseases (Cerebellar Syndrome) 10/2022
1	Cerebellar Ataxia (Dysmetria) 10/2022
1	Autonomic Nervous System Diseases (Dysautonomia) 10/2022
1	Atrophy 10/2022
1	Parkinsonian Disorders (Parkinsonism) 10/2022

Drug/Important Bio-Agent (IBA)

100	PrionsIBA 01/2024 - 10/2000
83	Prion ProteinsIBA 12/2023 - 03/2002
45	Proteins (Proteins, Gene)FDA Link 01/2024 - 01/2002
19	AntibodiesIBA 11/2023 - 05/2002
16	Protein Isoforms (Isoforms)IBA 12/2019 - 04/2003
12	Amyloid (Amyloid Fibrils)IBA 11/2023 - 01/2008
8	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 06/2004
6	Biomarkers (Surrogate Marker)IBA 11/2017 - 06/2006
5	AutoantibodiesIBA 10/2022 - 11/2012
5	tau Proteins (tau Protein)IBA 05/2021 - 09/2002
5	Messenger RNA (mRNA)IBA 01/2020 - 05/2002
5	Amyloid beta-PeptidesIBA 08/2010 - 02/2005
4	Immunoglobulin G (IgG)IBA 08/2022 - 01/2009
4	LigandsIBA 11/2021 - 07/2013
4	Codon (Codons)IBA 10/2020 - 06/2002
4	CytokinesIBA 01/2019 - 04/2004
3	RNA (Ribonucleic Acid)IBA 02/2024 - 10/2006
3	SynucleinsIBA 01/2021 - 12/2018
3	Endopeptidase K (Proteinase K)IBA 01/2020 - 01/2016
3	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2017 - 12/2014
3	Indicators and Reagents (Reagents)IBA 01/2017 - 06/2004
3	Protein AggregatesIBA 01/2016 - 01/2002
3	Peptides (Polypeptides)IBA 11/2014 - 02/2005
3	Lymphotoxin-alpha (Lymphotoxin)IBA 11/2012 - 12/2008
2	AA amyloidosisIBA 02/2024 - 04/2013
2	Complement System Proteins (Complement)IBA 01/2024 - 01/2011
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 11/2023 - 02/2005
2	alpha-SynucleinIBA 01/2023 - 10/2022
2	Prothrombin (Factor II)IBA 02/2022 - 12/2021
2	EnzymesIBA 01/2021 - 11/2017
2	Amyloidogenic ProteinsIBA 12/2018 - 02/2005
2	Monoclonal AntibodiesIBA 01/2018 - 11/2012
2	Complement Receptors (Complement Receptor)IBA 11/2017 - 11/2012
2	LipidsIBA 11/2017 - 11/2012
2	Nucleic AcidsIBA 11/2017 - 01/2008
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2017 - 02/2015
2	Everolimus FDA Link 01/2017 - 01/2016
2	Cell Surface ReceptorsIBA 05/2015 - 11/2014
2	14-3-3 Proteins (14-3-3 Protein)IBA 10/2012 - 10/2009
2	ThiophenesIBA 02/2010 - 08/2009
2	Phosphopyruvate Hydratase (Enolase)IBA 10/2009 - 05/2005
2	Type I Tumor Necrosis Factor ReceptorsIBA 06/2008 - 01/2002
2	Transcription Factors (Transcription Factor)IBA 07/2004 - 04/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2002 - 01/2002
1	Thrombin FDA Link 02/2024
1	Lysergic Acid Diethylamide (LSD)IBA 02/2024
1	Alanine (L-Alanine)FDA Link 01/2023
1	lysyl-aspartyl-glutamyl-leucineIBA 11/2022

Therapy/Procedure

10	Therapeutics 01/2023 - 07/2004
4	Immunotherapy 01/2023 - 10/2004
3	Blood Transfusion (Blood Transfusions) 01/2019 - 06/2006
1	Lasers (Laser) 02/2024
1	Thrombectomy 02/2024